CLASSIFICATION OF ANTIHYPERLIPIDEMIC DRUGS PDF

Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Chapter 18 Antihyperlipidemic Agents LEARNING OBJECTIVES Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics.

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Contraindication Where hepatic or renal function is severely impaired but gemfibrozil has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women PowerPoint Presentation: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Adverse effect of statins Transient, and minor abnormality of liver function tests Myopathy and rhabdomyolysis disintegration or dissolution of muscle and elevation of muscle enzymes creatine hosphokinaseCPK: Colesevelam Colestilan Colestipol Colestyramine Colextran.

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Antihyperlipidemic agents

Diabetes Mellitus with one of the primary hyperlipidaemias PowerPoint Presentation: Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein LDL cholesterol, some reduce triglyceride levels, and some help raise the high-density lipoprotein HDL cholesterol. Ezetimibe has no clinically meaningful effect on the plasma concentrations of the fat-soluble vitamins A, D, and E. Fibrates enhance the effect of co-administered oral Anticoagulants.

For example, some may lower the “bad cholesterol” low density lipoprotein LDL more so than others, while others may preferentially increase high density lipoprotein HDL”the good cholesterol”. Alpha- tocopherol acetate vitamin E Omega-3 marine triglycerides Maxepa Orlistat. You do not have the permission to view this presentation. Pravastatin and fluvastatin are almost completely absorbed after oral administration.

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Colesevelam has fewer gastrointestinal side effects and not Impaired absorptions PowerPoint Presentation: Define the pharmacophoric requirements of the statin class of antihyperlipidemics. As a regulator of homeostasis, a precursor to the corticosteroids and sex hormones, and a critical factor in the maintenance of cell-wall integrity, Their half-lives range from 1.

Familial mixed hypertriglyceridemia V: These drugs are often given in combination with other antihyperlipidemic drugs PowerPoint Presentation: Hypolipidemic agentsor antihyperlipidemic agentsare a diverse group of pharmaceuticals that are used in the treatment of high levels of fats lipidssuch as anyihyperlipidemic, in the blood hyperlipidemia. Therapeutic uses Hypertriglyceridemia the most effective in reduction TGs – combined hyperlipidemia type III if statins are contraindicated.

List of Antihyperlipidemic agents – Generics Only –

Antihyperlipieemica weight-reducing agent, it is pancreatic lipase inhibitor lowers the Glycaemia of diabetes mellitus to a antihyperlipdiemic that Accords with the weight loss, and improves Hyperlipidaemia There is a risk of steatorrhoea and alabsorption of Fat-soluble vitamins A, D and E. With Safari, you learn the way you learn best. By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease.

Hyperuricemia and gout Niacin inhibits tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity. They have no place in treating hypercholesterolaemia.

Pharmacokinetic of Fibric acid derivatives: To view content sources and attributions, please refer to our editorial policy. Type of hyperlipidemia Primary hyperlipidemia Secondary hyperlipidemia.

Tetracycline, warfarindigoxinthiazide diuretics, phenobarbitone and thyroid hormones should be taken 1 h-2h before or 4 h-6h after colestyramine to avoid impairment of their absorption Because the drug binds anions. Plasma creatine kinase levels should be determined regularly. Start Free Trial No credit card required.

Nicotinamide alone does not decrease plasma lipid levels. Niacin is administered orally. At high doses, cholestyramine and colestipol impair the absorption of the fat-soluble vitamins A, D, E, and K. They should not be used in children or teenagers. Mechanism of action of statins PowerPoint Presentation: Subscribe to free Drugs.

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Anti Hyperlipidemic Drugs |authorSTREAM

Niacin nicotinic acid Mechanism of action: Because of a circadian rhythm to LDL-receptor synthesis, statins are a little more effective if given in the evening rather than in the anttihyperlipidemic PowerPoint Presentation: Pharmacokinetic of Ezetimibe Metabolized in the small intestine and liver via glucuronide conjugation antinyperlipidemic Phase II reactionwith subsequent biliary and renal excretion.

In treatment of type IIA and IIB hyperlipidemias along with statins when response to statins is inadequate or they are contraindicated. Decongestants Bronchodilators Cough medicines H 1 antagonists. Contraindication Where hepatic or renal function is severely impaired but gemfibrozil has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women.

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Tetracycline, warfarindigoxinthiazide diuretics, phenobarbitone and thyroid hormones should be taken 1 h-2h before or 4 h-6h after colestyramine to avoid impairment of their absorption Because the drug binds anions Niacin nicotinic acid: Alpha- tocopherol acetate vitamin E Has no effect on lipid levels but is a powerful classiffication.

Go to Application Have a question? Stay ahead with the world’s most comprehensive technology and business learning platform. Clinically, the choice of an agent will depend on the patient’s cholesterol profilecardiovascular riskand the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications. ColesevelamColestipolCholestyramine Nicotinic acid: Mechanism of action of statins: Antihyperlipidemic agents promote reduction of lipid levels in the blood.